Novel bimetallic oxido-bridged phenolato hafniumIV complex with enhanced anti-tumor activity and aqueous stability | |
Zhao, Wenzhuo1; Yuan, Pengpeng1; Zhang, Qi1![]() ![]() | |
2023-12 | |
在线发表时间 | 2023-10 |
发表期刊 | RESULTS IN CHEMISTRY
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ISSN | 2211-7156 |
卷号 | 6 |
摘要 | A novel dimeric phenolato Hafnium complex [{HfIV(Salan2,4-Me)(OnBu)}2O] was synthesized by reacting [HfIV(Salan2,4-Me)2] in the presence of 100 equiv. of H2O. The structure was characterized by 1H, 13C No spectroscopy, HRMS and X-Ray diffraction. In comparison with [HfIV(Salan2,4-Me)2] and another precursor [{HfIV(Salan2,4-Me)(OnBu)}2O], this dimeric HfIV complex demonstrated enhanced aqueous stability and antitumor activity (IC50: 71.2 +/- 25.3 mu M against Hela S3 cells; 62.2 +/- 27.7 mu M against Hep G2 cells). Further-more, this dimeric HfIV complex can only be synthesized from [HfIV(Salan2,4-Me)2] in low equivalent of H2O, upon addition of 2,6-dipicolinic acid, it can be transformed to a Salan/Dipic HfIV bis-chelated complex. |
关键词 | Hafnium Anti -tumor activity Hydrolytic stability 6-Dipicolinic acid Phenolato ligands Polydentate Schiff bases |
DOI | 10.1016/j.rechem.2023.101161 |
收录类别 | ESCI |
语种 | 英语 |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Multidisciplinary |
WOS记录号 | WOS:001098606200001 |
出版者 | ELSEVIER |
原始文献类型 | Article |
引用统计 | 无
|
文献类型 | 期刊论文 |
条目标识符 | https://ir.lut.edu.cn/handle/2XXMBERH/166979 |
专题 | 法学院 生命科学与工程学院 |
通讯作者 | Zhao, Tiankun |
作者单位 | 1.Lanzhou Univ Technol, Coll Life Sci & Engn, Lanzhou 730050, Peoples R China; 2.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China; 3.Univ Konstanz, Fachbereich Chem, Univ Str 10, D-78457 Constance, Germany |
第一作者单位 | 生命科学与工程学院 |
通讯作者单位 | 生命科学与工程学院 |
第一作者的第一单位 | 生命科学与工程学院 |
推荐引用方式 GB/T 7714 | Zhao, Wenzhuo,Yuan, Pengpeng,Zhang, Qi,et al. Novel bimetallic oxido-bridged phenolato hafniumIV complex with enhanced anti-tumor activity and aqueous stability[J]. RESULTS IN CHEMISTRY,2023,6. |
APA | Zhao, Wenzhuo.,Yuan, Pengpeng.,Zhang, Qi.,Liu, Nan.,Wang, Yulai.,...&Zhao, Tiankun.(2023).Novel bimetallic oxido-bridged phenolato hafniumIV complex with enhanced anti-tumor activity and aqueous stability.RESULTS IN CHEMISTRY,6. |
MLA | Zhao, Wenzhuo,et al."Novel bimetallic oxido-bridged phenolato hafniumIV complex with enhanced anti-tumor activity and aqueous stability".RESULTS IN CHEMISTRY 6(2023). |
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