Novel bimetallic oxido-bridged phenolato hafniumIV complex with enhanced anti-tumor activity and aqueous stability

doi:10.1016/j.rechem.2023.101161

IR > 法学院

	Novel bimetallic oxido-bridged phenolato hafniumIV complex with enhanced anti-tumor activity and aqueous stability
	Zhao, Wenzhuo 1; Yuan, Pengpeng 1; Zhang, Qi1 ; Liu, Nan 1; Wang, Yulai 2; Wang, Peng 1; Huhn, Thomas 3; Yang, Zhongduo1 ; Zhao, Tiankun 1
	2023-12
在线发表时间	2023-10
发表期刊	RESULTS IN CHEMISTRY
ISSN	2211-7156
卷号	6
摘要	A novel dimeric phenolato Hafnium complex [{HfIV(Salan2,4-Me)(OnBu)}2O] was synthesized by reacting [HfIV(Salan2,4-Me)2] in the presence of 100 equiv. of H2O. The structure was characterized by 1H, 13C No spectroscopy, HRMS and X-Ray diffraction. In comparison with [HfIV(Salan2,4-Me)2] and another precursor [{HfIV(Salan2,4-Me)(OnBu)}2O], this dimeric HfIV complex demonstrated enhanced aqueous stability and antitumor activity (IC50: 71.2 +/- 25.3 mu M against Hela S3 cells; 62.2 +/- 27.7 mu M against Hep G2 cells). Further-more, this dimeric HfIV complex can only be synthesized from [HfIV(Salan2,4-Me)2] in low equivalent of H2O, upon addition of 2,6-dipicolinic acid, it can be transformed to a Salan/Dipic HfIV bis-chelated complex.
关键词	Hafnium Anti -tumor activity Hydrolytic stability 6-Dipicolinic acid Phenolato ligands Polydentate Schiff bases
DOI	10.1016/j.rechem.2023.101161
收录类别	ESCI
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:001098606200001
出版者	ELSEVIER
原始文献类型	Article
引用统计	无
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/166979
专题	法学院生命科学与工程学院
通讯作者	Zhao, Tiankun
作者单位	1.Lanzhou Univ Technol, Coll Life Sci & Engn, Lanzhou 730050, Peoples R China; 2.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China; 3.Univ Konstanz, Fachbereich Chem, Univ Str 10, D-78457 Constance, Germany
第一作者单位	生命科学与工程学院
通讯作者单位	生命科学与工程学院
第一作者的第一单位	生命科学与工程学院
推荐引用方式 GB/T 7714	Zhao, Wenzhuo,Yuan, Pengpeng,Zhang, Qi,et al. Novel bimetallic oxido-bridged phenolato hafniumIV complex with enhanced anti-tumor activity and aqueous stability[J]. RESULTS IN CHEMISTRY,2023,6.
APA	Zhao, Wenzhuo.,Yuan, Pengpeng.,Zhang, Qi.,Liu, Nan.,Wang, Yulai.,...&Zhao, Tiankun.(2023).Novel bimetallic oxido-bridged phenolato hafniumIV complex with enhanced anti-tumor activity and aqueous stability.RESULTS IN CHEMISTRY,6.
MLA	Zhao, Wenzhuo,et al."Novel bimetallic oxido-bridged phenolato hafniumIV complex with enhanced anti-tumor activity and aqueous stability".RESULTS IN CHEMISTRY 6(2023).