Institutional Repository of Coll Life & Sci Engn
Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres | |
Zhao, Xiaoliang1; Wang, Yuting1; Pu, Xiuying1; Ma, Jianzhong1; Leng, Feifan1; Wang, Yonggang1; Wang, Yanling1; Yang, Shuhong1; Ran, Fen2; Zhang, Weijie1 | |
2019 | |
发表期刊 | JOURNAL OF RENEWABLE MATERIALS |
ISSN | 2164-6325 |
卷号 | 7期号:12页码:1321-1332 |
摘要 | A series of the Guiqi polysaccharides/chitosan/alginate composite hydrogel microspheres (GPcM) with different particle sizes were prepared with Guiqi polysaccharides (GP), chitosan (CS) and sodium alginate (Alg). The optimum preparation process was also determined by single factor and orthogonal experiment analysis. The GPcM were characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), drug loading efficiency test (LE), encapsulation efficiency test (EE) and in vitro release study. The results showed that the Guiqi polysaccharides chitosan hydrogel (GPCH) and sodium alginate hydrogel (SAH) formed a crossover system in GPcM. The GPcM have a uniform particle size ranging from 395.1 mu m to 841.5 mu m. The drug loading efficiency and encapsulation efficiency of the GPcM were 56.3% and 72.6%, respectively. The bovine serum albumin (BSA) loaded in the GPcM released slowly within 180 h. The results suggested that the GPcM may have potential application value in drug sustained and controlled release system. |
关键词 | Guiqi polysaccharides composite hydrogel microspheres cross-linker drug loading |
DOI | 10.32604/jrm.2019.07757 |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[81560737][31860250] ; Natural Science Foundation of Gansu Province[18JR3RA148] ; Guangxi Provincial Natural Science Fund of China[2016GXNSFAA380234] ; Fundamental Research Funds for Key Laboratory of Drug Screening and Deep Processing for Traditional Chinese and Tibetan Medicine of Gansu Province[20180801] |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Polymer Science |
WOS类目 | Green & Sustainable Science & Technology ; Materials Science, Composites ; Polymer Science |
WOS记录号 | WOS:000503231400006 |
出版者 | TECH SCIENCE PRESS |
EI入藏号 | 20212810629799 |
EI主题词 | Controlled drug delivery |
EI分类号 | 549.1 Alkali Metals - 801 Chemistry - 804 Chemical Products Generally - 804.1 Organic Compounds - 913.1 Production Engineering - 951 Materials Science |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://ir.lut.edu.cn/handle/2XXMBERH/64298 |
专题 | 生命科学与工程学院 材料科学与工程学院 |
通讯作者 | Zhang, Weijie |
作者单位 | 1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China; 2.Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Gansu, Peoples R China |
第一作者单位 | 生命科学与工程学院 |
通讯作者单位 | 生命科学与工程学院 |
第一作者的第一单位 | 生命科学与工程学院 |
推荐引用方式 GB/T 7714 | Zhao, Xiaoliang,Wang, Yuting,Pu, Xiuying,et al. Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres[J]. JOURNAL OF RENEWABLE MATERIALS,2019,7(12):1321-1332. |
APA | Zhao, Xiaoliang.,Wang, Yuting.,Pu, Xiuying.,Ma, Jianzhong.,Leng, Feifan.,...&Zhang, Weijie.(2019).Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres.JOURNAL OF RENEWABLE MATERIALS,7(12),1321-1332. |
MLA | Zhao, Xiaoliang,et al."Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres".JOURNAL OF RENEWABLE MATERIALS 7.12(2019):1321-1332. |
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