Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres
Zhao, Xiaoliang1; Wang, Yuting1; Pu, Xiuying1; Ma, Jianzhong1; Leng, Feifan1; Wang, Yonggang1; Wang, Yanling1; Yang, Shuhong1; Ran, Fen2; Zhang, Weijie1
2019
Source PublicationJOURNAL OF RENEWABLE MATERIALS
ISSN2164-6325
Volume7Issue:12Pages:1321-1332
Abstract

A series of the Guiqi polysaccharides/chitosan/alginate composite hydrogel microspheres (GPcM) with different particle sizes were prepared with Guiqi polysaccharides (GP), chitosan (CS) and sodium alginate (Alg). The optimum preparation process was also determined by single factor and orthogonal experiment analysis. The GPcM were characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), drug loading efficiency test (LE), encapsulation efficiency test (EE) and in vitro release study. The results showed that the Guiqi polysaccharides chitosan hydrogel (GPCH) and sodium alginate hydrogel (SAH) formed a crossover system in GPcM. The GPcM have a uniform particle size ranging from 395.1 mu m to 841.5 mu m. The drug loading efficiency and encapsulation efficiency of the GPcM were 56.3% and 72.6%, respectively. The bovine serum albumin (BSA) loaded in the GPcM released slowly within 180 h. The results suggested that the GPcM may have potential application value in drug sustained and controlled release system.

KeywordGuiqi polysaccharides composite hydrogel microspheres cross-linker drug loading
DOI10.32604/jrm.2019.07757
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81560737][31860250] ; Natural Science Foundation of Gansu Province[18JR3RA148] ; Guangxi Provincial Natural Science Fund of China[2016GXNSFAA380234] ; Fundamental Research Funds for Key Laboratory of Drug Screening and Deep Processing for Traditional Chinese and Tibetan Medicine of Gansu Province[20180801]
WOS Research AreaScience & Technology - Other Topics ; Materials Science ; Polymer Science
WOS SubjectGreen & Sustainable Science & Technology ; Materials Science, Composites ; Polymer Science
WOS IDWOS:000503231400006
PublisherTECH SCIENCE PRESS
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lut.edu.cn/handle/2XXMBERH/64298
Collection生命科学与工程学院
材料科学与工程学院
Corresponding AuthorZhang, Weijie
Affiliation1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China
2.Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Gansu, Peoples R China
First Author AffilicationColl Life & Sci Engn
Corresponding Author AffilicationColl Life & Sci Engn
First Signature AffilicationColl Life & Sci Engn
Recommended Citation
GB/T 7714
Zhao, Xiaoliang,Wang, Yuting,Pu, Xiuying,et al. Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres[J]. JOURNAL OF RENEWABLE MATERIALS,2019,7(12):1321-1332.
APA Zhao, Xiaoliang.,Wang, Yuting.,Pu, Xiuying.,Ma, Jianzhong.,Leng, Feifan.,...&Zhang, Weijie.(2019).Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres.JOURNAL OF RENEWABLE MATERIALS,7(12),1321-1332.
MLA Zhao, Xiaoliang,et al."Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres".JOURNAL OF RENEWABLE MATERIALS 7.12(2019):1321-1332.
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