Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment

doi:10.1002/cbdv.202200295

	Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment
	Si, Xiao-Li 1,2; Wang, Yan 2,3; Song, Bo-Ni 4; Zhang, Yan 1; Yang, Qing-Xia 1; Li, Zhi 4; Luo, Yan-Ping 1; Duan, Yong-Qiang 2,5; Ma, Xing-Ming 1; Zhang, Yan-Ying 6
	2022-08
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	19 期号:8
摘要	Chronic inflammation plays a positive role in the development and progression of colitis-associated colorectal cancer (CAC). Medicinal plants and their extracts with anti-inflammatory and immunoregulatory properties may be an effective treatment and prevention strategy for CAC. This research aimed to explore the potential chemoprevention of paeoniflorin (PF) for CAC by network pharmacology, molecular docking technology, and in vivo experiments. The results showed that interleukin-6 (IL-6) is a key target of PF against CAC. In the CAC mouse model, PF increased the survival rate of mice and decreased the number and size of colon tumors. Moreover, reduced histological score of colitis and expression of Ki-67 and PCNA were observed in PF-treated mice. In addition, the chemoprevention mechanisms of PF in CAC may be associated with suppression of the IL-6/STAT3 signaling pathway and the IL-17 level. This research provides experimental evidence of potential chemoprevention strategies for CAC treatment.
关键词	network pharmacology molecular docking paeoniflorin colitis-associated colorectal cancer IL-6 STAT3
DOI	10.1002/cbdv.202200295
收录类别	SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000837201200001
出版者	WILEY-V C H VERLAG GMBH
来源库	WOS
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/159852
专题	兰州理工大学
通讯作者	Zhang, Yan; Ma, Xing-Ming
作者单位	1.Lanzhou Univ, Sch Basic Med Sci, Dept Immunol, 199 West Donggang Rd, Lanzhou 730030, Peoples R China; 2.Gansu Univ Chinese Med, Sch Basic Med Sci, 35 East Dingxi Rd, Lanzhou 730030, Peoples R China; 3.Ningxia Med Univ, Sch Tradit Chinese Med, 1160 Victory St, Yinchuan 750004, Ningxia, Peoples R China; 4.Lanzhou Univ Technol, Sch Life Sci & Engn, 287 LanGongPing Rd, Lanzhou 730050, Peoples R China; 5.Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat, Minist Educ, 35 East Dingxi Rd, Lanzhou 730030, Peoples R China; 6.Gansu Univ Chinese Med, Sci Res & Expt Ctr, 35 East Dingxi Rd, Lanzhou 730030, Peoples R China
推荐引用方式 GB/T 7714	Si, Xiao-Li,Wang, Yan,Song, Bo-Ni,et al. Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment[J]. CHEMISTRY & BIODIVERSITY,2022,19(8).
APA	Si, Xiao-Li.,Wang, Yan.,Song, Bo-Ni.,Zhang, Yan.,Yang, Qing-Xia.,...&Zhang, Yan-Ying.(2022).Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment.CHEMISTRY & BIODIVERSITY,19(8).
MLA	Si, Xiao-Li,et al."Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment".CHEMISTRY & BIODIVERSITY 19.8(2022).