A Novel Molecularly Imprinted Electrochemical Sensor Based on PANI@GO for Highly Sensitive and Selective Analysis of Trace Epigoitrin

doi:10.1149/1945-7111/ac8508

	A Novel Molecularly Imprinted Electrochemical Sensor Based on PANI@GO for Highly Sensitive and Selective Analysis of Trace Epigoitrin
	Sun, Bolu1 ; Gao, Chengyang 1; Yang, Lin1 ; Shi, Hongxia 2; Kan, Lei 1; Ma, Quhuan 3; Shi, Xiaofeng 3
	2022-08-01
发表期刊	JOURNAL OF THE ELECTROCHEMICAL SOCIETY
ISSN	0013-4651
卷号	169 期号:8
摘要	Identification and quantification of epigoitrin (EP) in some herbs and traditional Chinese medicine (TCM) preparations are critical to pharmacokinetic study and pharmaceutical quality control due to its distinct antiviral activity. So, developing highly sensitive and selective method for detection of EP is essential for clinical treatment and drug development. In this study, a novel molecularly imprinted electrochemical sensor for detection of EP was firstly constructed. With acrylamide imprinting systems, surface imprinting on the polyaniline functionalized graphene oxide was employed to prepare molecularly imprinted polymer by electro-polymerization, which follow-up constructed afford specific binding cavities, endowing the exclusive recognition ability. Furthermore, the polyacrylamide chain is anchored to the polyaniline chain by covalent bonds, which is beneficial for raising electrochemistry signal. Under the optimized condition, the sensor demonstrates a linear wide range of 4.6 x 10(-7) mol l(-1) similar to 4.6 x 10(-5) mol l(-1) with a correlation coefficient of 0.9953 and a low LOD of 8.21 x 10(-8) mol l(-1) (S/N = 3). Additionally, the sensor showed good stability, repeatability (RSD 1.52%) and selectivity. The method was applied to analyze EP in the extraction from Isatidis Radix with a recovery higher than 97.8% and RSD less than 1.81%. This work provided a novel strategy for on-site, realtime and rapid detection of indicator components from TCM. (C) 2022 The Electrochemical Society (ECS). Published on behalf of ECS by IOP Publishing Limited.
关键词	Trace epigoitrin Molecularly imprinted electrochemical sensor (MIES) Polyaniline functionalized graphene oxide (PANI@GO) Highly selective recognition
DOI	10.1149/1945-7111/ac8508
收录类别	SCIE
语种	英语
WOS研究方向	Electrochemistry ; Materials Science
WOS类目	Electrochemistry ; Materials Science, Coatings & Films
WOS记录号	WOS:000835780500001
出版者	ELECTROCHEMICAL SOC INC
来源库	WOS
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/159828
专题	生命科学与工程学院
通讯作者	Sun, Bolu; Yang, Lin; Shi, Hongxia; Shi, Xiaofeng
作者单位	1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Gansu, Peoples R China; 2.Lanzhou Zhongjianke Testing Technol Co Ltd, Lanzhou 730000, Gansu, Peoples R China; 3.Gansu Acad Med Sci, Lanzhou 730050, Peoples R China
第一作者单位	生命科学与工程学院
通讯作者单位	生命科学与工程学院
第一作者的第一单位	生命科学与工程学院
推荐引用方式 GB/T 7714	Sun, Bolu,Gao, Chengyang,Yang, Lin,et al. A Novel Molecularly Imprinted Electrochemical Sensor Based on PANI@GO for Highly Sensitive and Selective Analysis of Trace Epigoitrin[J]. JOURNAL OF THE ELECTROCHEMICAL SOCIETY,2022,169(8).
APA	Sun, Bolu.,Gao, Chengyang.,Yang, Lin.,Shi, Hongxia.,Kan, Lei.,...&Shi, Xiaofeng.(2022).A Novel Molecularly Imprinted Electrochemical Sensor Based on PANI@GO for Highly Sensitive and Selective Analysis of Trace Epigoitrin.JOURNAL OF THE ELECTROCHEMICAL SOCIETY,169(8).
MLA	Sun, Bolu,et al."A Novel Molecularly Imprinted Electrochemical Sensor Based on PANI@GO for Highly Sensitive and Selective Analysis of Trace Epigoitrin".JOURNAL OF THE ELECTROCHEMICAL SOCIETY 169.8(2022).