Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A

doi:10.1016/j.phytol.2021.11.006

IR > 石油化工学院

	Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A
	Wang, Sha 1,2; Zeng, Yanbo 2; Yin, Jianjun1 ; Chang, Wenjun 2; Zhao, Xiaoliang1 ; Mao, Yu 1,2
	2022-02
发表期刊	PHYTOCHEMISTRY LETTERS
ISSN	1874-3900
卷号	47 页码:76-80
摘要	Two new azaphilones, penicilazaphilones F (1) and G (2) together with two known analogs (3 and 4), were isolated from fermentation cultures of the marine-derived fungus Penicillium sclerotiorum E23Y-1A. Their structures were elucidated based on spectroscopic methods, including IR, MS, 1D and 2D NMR, as well as by comparison with published data. The absolute configuration of compound 1 was unambiguously determined using electronic circular dichroism (ECD) calculation. All isolated compounds were evaluated for their anti-inflammatory effects. Compounds 1-4 inhibited the lipopolysaccharide-induced production of nitric oxide (NO) in BV-2 cells, with IC50 values of 31.7 +/- 1.5, 34.5 +/- 1.4, 25.3 +/- 2.2, and 34.8 +/- 1.9 mu M, respectively. In contrast, these compounds showed no obvious cytotoxicity at a concentration of 50.0 mu M.
关键词	Azaphilone Marine-derived fungus Penicillium sclerotiorum Metabolite Anti-inflammatory
DOI	10.1016/j.phytol.2021.11.006
收录类别	SCIE
语种	英语
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Medicinal
WOS记录号	WOS:000800560300004
出版者	ELSEVIER
来源库	WOS
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/158894
专题	石油化工学院生命科学与工程学院
通讯作者	Zeng, Yanbo
作者单位	1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China; 2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliz, Haikou 571101, Hainan, Peoples R China
第一作者单位	生命科学与工程学院
第一作者的第一单位	生命科学与工程学院
推荐引用方式 GB/T 7714	Wang, Sha,Zeng, Yanbo,Yin, Jianjun,et al. Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A[J]. PHYTOCHEMISTRY LETTERS,2022,47:76-80.
APA	Wang, Sha,Zeng, Yanbo,Yin, Jianjun,Chang, Wenjun,Zhao, Xiaoliang,&Mao, Yu.(2022).Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A.PHYTOCHEMISTRY LETTERS,47,76-80.
MLA	Wang, Sha,et al."Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A".PHYTOCHEMISTRY LETTERS 47(2022):76-80.