Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats

doi:10.1177/08853282211054333

	Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats
	Yang, Mingjun 1; Jin, Yongming 1; Yang, Jumei 2; Wang, Chenliang 1; Wang, Xinjian 1; Wang, Yonggang1
	2022-05
发表期刊	Journal of Biomaterials Applications
ISSN	0885-3282
卷号	36 期号:10 页码:1723-1736
摘要	In this study, after optimizing the extraction process of CPP (Codonopsis pilosula polysaccharides), CPPM (CPP microcapsules) were prepared. Subsequently, the structural characteristics and physicochemical properties were studied. The results showed that CPPM is a hollow sac-like structure with rough folds and protuberances and comes in spherical or ellipsoidal shapes with uniform particle size. CPPM has certain swelling degree, low hardness, good adhesion, and stability. Then, the effect of CPPM on wounds repair was investigated by a rat model. The results showed that CPPM could improve the wound healing rate. Histological evaluation showed CPPM could promote neovascularization and fibroblast proliferation. By investigating the healing mechanism, it was found that CPPM increased the hydroxyproline content in granulation tissue and had an excellent antioxidant ability, and then inhibited lipid peroxidation, in addition, it significantly increased the transcript levels of VEGF and miRNA-21 genes, indicating that CPPM play an influential role in vascular remodeling during wound healing by up-regulating the expression of VEGF and miRNA-21 genes. © The Author(s) 2022.
关键词	Cell culture Genes Particle size Physicochemical properties Polysaccharides Rats RNA Tissue regeneration Characteristic properties Codonopsi pilosulum polysaccharide Extraction process Microcapsules Particles sizes Physicochemical property Rat model Structural characteristics Swelling degree Wound healing
DOI	10.1177/08853282211054333
收录类别	EI ; SCIE
语种	英语
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000764247800001
出版者	SAGE Publications Ltd
EI入藏号	20221111775913
EI主题词	Microstructure
EI分类号	461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 801.4 Physical Chemistry ; 804.1 Organic Compounds ; 815.1.1 Organic Polymers ; 951 Materials Science
来源库	WOS
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/157922
专题	生命科学与工程学院
通讯作者	Wang, Yonggang
作者单位	1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Peoples R China; 2.Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China
第一作者单位	生命科学与工程学院
通讯作者单位	生命科学与工程学院
第一作者的第一单位	生命科学与工程学院
推荐引用方式 GB/T 7714	Yang, Mingjun,Jin, Yongming,Yang, Jumei,et al. Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats[J]. Journal of Biomaterials Applications,2022,36(10):1723-1736.
APA	Yang, Mingjun,Jin, Yongming,Yang, Jumei,Wang, Chenliang,Wang, Xinjian,&Wang, Yonggang.(2022).Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats.Journal of Biomaterials Applications,36(10),1723-1736.
MLA	Yang, Mingjun,et al."Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats".Journal of Biomaterials Applications 36.10(2022):1723-1736.