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Isolation and Identification of New Impurities in Nomegestrol Acetate | |
Yang Zhong-duo2,4; Zhang Xu2; Li Tao2; Li Yuan-chao1; Wang You-fu3 | |
2009-09-02 | |
发表期刊 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES |
ISSN | 1005-9040 |
卷号 | 25期号:5页码:653-656 |
摘要 | Three new and five known steroidal compounds as impurities in nomegestrol acetate(I) were isolated from the enriched mother liquor via various chromatographic methods. Their structures were elucidated by spectrometric analysis and single-crystal X-ray diffraction analysis. New compounds were characterized as 17 alpha-hydroxyl-3-oxoes-trane-5 beta,17-dicarbonitrile(1), 4-ethyl-17 alpha-hydroxyl-3-oxoestr-4-en-17-carbonitrile(2), 4-ethylestr-4-en-3,17-dione(3). The C-13 NMR data of known estrane derivatives(4-7) were also reported first time in this paper. The study may be helpful to identifing and characterizing all the impurities that are present at a level of 0.1% and be useful in the quality control of the production of nomegestrol acetate. |
关键词 | Steroid Nomegestrol acetate Estrane derivative |
收录类别 | SCIE |
语种 | 英语 |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Multidisciplinary |
WOS记录号 | WOS:000271081900013 |
出版者 | HIGHER EDUCATION PRESS |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://ir.lut.edu.cn/handle/2XXMBERH/155565 |
专题 | 生命科学与工程学院 机电工程学院 |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China; 3.Xianju Pharmaceut Factory, Branch Factory 2, Xianju 317300, Peoples R China; 4.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China |
第一作者单位 | 生命科学与工程学院 |
第一作者的第一单位 | 生命科学与工程学院 |
推荐引用方式 GB/T 7714 | Yang Zhong-duo,Zhang Xu,Li Tao,et al. Isolation and Identification of New Impurities in Nomegestrol Acetate[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2009,25(5):653-656. |
APA | Yang Zhong-duo,Zhang Xu,Li Tao,Li Yuan-chao,&Wang You-fu.(2009).Isolation and Identification of New Impurities in Nomegestrol Acetate.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,25(5),653-656. |
MLA | Yang Zhong-duo,et al."Isolation and Identification of New Impurities in Nomegestrol Acetate".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 25.5(2009):653-656. |
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