Higher Bioavailability of Organic Bound Zinc from High Zinc-Enriched Fungi

doi:10.1024/0300-9831/a000214

	Higher Bioavailability of Organic Bound Zinc from High Zinc-Enriched Fungi
	Zhang, Xin-Guo; Peng, Yi-Nan; Li, Xiao-Ru; Ma, Guo-Di; Wang, Ming-Gang
	2014
发表期刊	INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
ISSN	0300-9831
卷号	84 期号:5-6 页码:277-285
摘要	The organic forms of trace elements are considered more bioavailable than the inorganic forms. Although yeast can enrich metal elements and convert inorganic zinc to organic species, its tolerability and transforming capacity are limited. It would therefore be very interesting to look for higher conversion and accumulation in zinc fungi to obtain organic bound zinc from the natural environment. In this paper, potato dextrose agar (PDA) medium containing 800 mu g/mL zinc was used for initial screening, with twenty-two fungal strains that tolerated high zinc isolated from the natural environment, and one strain (No.LZ-1108) growing well at a zinc (II) concentration of 10,000 mu g/mL. According to morphological analysis, 18S rDNA sequence analysis, and biophysical and biochemical characteristics, No.LZ-1108 was tentatively identified as Fusarium oxysporum. Using atomic absorption spectrometry, the zinc content in the No.LZ-1108 cells was found to be 6.7 mg/g dry cell. After oral administration to rats at a dose of 10 mg Zn (II)/kg body weight, the area under the plasma concentration-time curve (AUC) and the maximum zinc blood concentration (Cmax) of No.LZ-1108 and zinc gluconate were 8.10 g/L.min and 4.28 g/L.min, 23.72 mu g/mL and 6.23 mu g/mL, respectively. The AUC of No.LZ-1108 was significantly higher than those of zinc gluconate (P<0.05), and the mean relative bioavailability of AUC(test)/AUC(zinc gluconate) was 190 %, which showed that the bound zinc in No.LZ-1108 was more bioavailable than zinc gluconate. The present study reports an interesting alternative to developing zinc-based supplements from a natural source of zinc.
关键词	high-zinc-enriched fungi organic bound zinc bioavailability
DOI	10.1024/0300-9831/a000214
收录类别	SCIE
语种	英语
WOS研究方向	Nutrition & Dietetics
WOS类目	Nutrition & Dietetics
WOS记录号	WOS:000359510100007
出版者	VERLAG HANS HUBER
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/155520
专题	生命科学与工程学院高等教育研究所（教学质量监督与评估工作办公室、本科教学督导委员会研究生督导委员会）
通讯作者	Zhang, Xin-Guo
作者单位	Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China
第一作者单位	生命科学与工程学院
通讯作者单位	生命科学与工程学院
第一作者的第一单位	生命科学与工程学院
推荐引用方式 GB/T 7714	Zhang, Xin-Guo,Peng, Yi-Nan,Li, Xiao-Ru,et al. Higher Bioavailability of Organic Bound Zinc from High Zinc-Enriched Fungi[J]. INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH,2014,84(5-6):277-285.
APA	Zhang, Xin-Guo,Peng, Yi-Nan,Li, Xiao-Ru,Ma, Guo-Di,&Wang, Ming-Gang.(2014).Higher Bioavailability of Organic Bound Zinc from High Zinc-Enriched Fungi.INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH,84(5-6),277-285.
MLA	Zhang, Xin-Guo,et al."Higher Bioavailability of Organic Bound Zinc from High Zinc-Enriched Fungi".INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH 84.5-6(2014):277-285.