Institutional Repository of Coll Life & Sci Engn
| Antitumor activity of a Rhodococcus sp Lut0910 isolated from polluted soil | |
Zhang, Xin-Guo1,2 ; Liu, Zi-Yu1,2; Liu, Jin-Wen1,2; Zeng, Yan-Long1,2; Guo, Guang-Jun1,2; Sun, Qiao-Yun1,2
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| 2017-06-22 | |
| 发表期刊 | TUMOR BIOLOGY
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| ISSN | 1010-4283 |
| 卷号 | 39期号:6 |
| 摘要 | The actinomycetes strain, lut0910, was isolated from polluted soil and identified as the Rhodococcus species with 99% similarity based on the sequence analysis of 16S recombinant DNA. The extract of this strain demonstrated in vivo and in vitro antitumor activity. The treatment of two human cancer cell lines, hepatocellular carcinoma HepG2 and cervical carcinoma Hela cells, with the lut0910 extract caused the delay in cell propagation in a dose-dependent manner with an IC50 of 73.39 and 33.09 mu g/mL, respectively. Also, the oral administration of lut0910 extract to the mice with a solid tumor resulted in the inhibition of tumor growth in comparison with a placebo group. The thymus and spleen indexes were significantly increased in mice groups treated with the lut0910 extract. The histopathological changes of the tumor tissues showed that there were massive necrotic areas in the tumor tissues after treatment with different doses of the lut0910 extract. Our result would provide a new way and potent source for development of new anticancer agent from the polluted environment. |
| 关键词 | Actinomycetes polluted soil Rhodococcus sp antitumor activity |
| DOI | 10.1177/1010428317711661 |
| 收录类别 | SCIE |
| 语种 | 英语 |
| WOS研究方向 | Oncology |
| WOS类目 | Oncology |
| WOS记录号 | WOS:000404157200001 |
| 出版者 | SAGE PUBLICATIONS LTD |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://ir.lut.edu.cn/handle/2XXMBERH/155429 |
| 专题 | 生命科学与工程学院 |
| 通讯作者 | Zhang, Xin-Guo |
| 作者单位 | 1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China; 2.Key Lab Screening & Proc New Tibetan Med Gansu Pr, Gansu, Peoples R China |
| 第一作者单位 | 生命科学与工程学院 |
| 通讯作者单位 | 生命科学与工程学院 |
| 第一作者的第一单位 | 生命科学与工程学院 |
| 推荐引用方式 GB/T 7714 | Zhang, Xin-Guo,Liu, Zi-Yu,Liu, Jin-Wen,et al. Antitumor activity of a Rhodococcus sp Lut0910 isolated from polluted soil[J]. TUMOR BIOLOGY,2017,39(6). |
| APA | Zhang, Xin-Guo,Liu, Zi-Yu,Liu, Jin-Wen,Zeng, Yan-Long,Guo, Guang-Jun,&Sun, Qiao-Yun.(2017).Antitumor activity of a Rhodococcus sp Lut0910 isolated from polluted soil.TUMOR BIOLOGY,39(6). |
| MLA | Zhang, Xin-Guo,et al."Antitumor activity of a Rhodococcus sp Lut0910 isolated from polluted soil".TUMOR BIOLOGY 39.6(2017). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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