Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo

doi:10.1166/nnl.2020.3240

	Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo
	Liu, Bing1 ; Ding, De 1; Zhao, Ping1 ; Zhang, Xinguo1 ; Tian, Zhenji 2; Xia, Xingxing 1; Zhang, Zihao 1
	2020-11
发表期刊	NANOSCIENCE AND NANOTECHNOLOGY LETTERS
ISSN	1941-4900
卷号	12 期号:11 页码:1337-1343
摘要	In order to confirm whether HSFL (the fermented liquor of mycelia of Hirsutella sinensis) still contains cordycepin, Cordyceps polysaccharide and other functional components, and has the functions of anti-oxidation, tumor inhibition and immunity enhancement, the biological activity of HSFL in vivo and in vitro was studied in this study. The transformation ability of mouse spleen lymphocytes induced by ConA, the activity of NK cells in mouse spleen, the delayed allergic reaction induced by DNFB and the phagocytosis of chicken red cells by mouse peritoneal macrophages were studied. The results showed that when the concentration of HSFL was 0.5972 mg/kg and 1.1944 mg/kg, the transformation of lymphocytes induced by ConA and the activity of NK cells were significantly increased. HSFL also can significantly improve DNFB induced anaphylaxis in mice and phagocytosis of chicken erythrocytes by peritoneal macrophages in mice when the dose of HSFL is 50 mg/kg and 75 mg/kg, indicating that HSFL has the biological activity of enhancing immunity in vitro and in vivo.
关键词	Hirsutella sinensis Ghostmoth Mycelium Fermentation Immunomodulatory Activity
DOI	10.1166/nnl.2020.3240
收录类别	SCIE
语种	英语
WOS研究方向	Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000610459800012
出版者	AMER SCIENTIFIC PUBLISHERS
来源库	WOS
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/155060
专题	生命科学与工程学院
通讯作者	Zhao, Ping
作者单位	1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China; 2.Lanzhou Univ Technol, Sch Sci, Lanzhou 730050, Peoples R China
第一作者单位	生命科学与工程学院
通讯作者单位	生命科学与工程学院
第一作者的第一单位	生命科学与工程学院
推荐引用方式 GB/T 7714	Liu, Bing,Ding, De,Zhao, Ping,et al. Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo[J]. NANOSCIENCE AND NANOTECHNOLOGY LETTERS,2020,12(11):1337-1343.
APA	Liu, Bing.,Ding, De.,Zhao, Ping.,Zhang, Xinguo.,Tian, Zhenji.,...&Zhang, Zihao.(2020).Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo.NANOSCIENCE AND NANOTECHNOLOGY LETTERS,12(11),1337-1343.
MLA	Liu, Bing,et al."Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo".NANOSCIENCE AND NANOTECHNOLOGY LETTERS 12.11(2020):1337-1343.