Synthesis and anti-tumor activity of cyclodepsipeptides paecilodepsipeptide A

doi:10.4028/www.scientific.net/AMR.643.92

	Synthesis and anti-tumor activity of cyclodepsipeptides paecilodepsipeptide A
	Yang, Mingjun 1,2; Wang, Yonggang1 ; Liu, Xiaofeng1 ; Wu, Jing 1
	2013
会议名称	2012 International Conference on Biochemical Materials and Nanotechnology Application, BMNA 2012
会议录名称	Advanced Materials Research
卷号	643
页码	92-96
会议日期	December 22, 2012 - December 23, 2012
会议地点	Yichang, China
出版者	Trans Tech Publications, P.O. Box 1254, Clausthal-Zellerfeld, D-38670, Germany
摘要	Paecilodepsipeptide A was first synthesized by retrosynthesis methods. the structures were determined by Mass Spectrometry and NMR spectroscopy, and the anti-tumor activities on human hepatocellular carcinoma cell line (SMMC-7721) and human lymphoma cell line (Raji) were examined by MTT. The result showed that the rate of Paecilodepsipeptide A was 72% by retrosynthesis methods. The structures of the synthesized product were identified by 1H NMR and 13C NMR spectra, which is identical to the natural product. The product has remarkable anti-proliferation activity on SMMC-7721 and Raji, which showed good anti-tumor activity. IC50 was 8.97 μmol/L and 11.13 μmol/L respectively, The total synthesis of Paecilodepsipeptide A is significant to further study its derivatives and develop novel antitumor drugs. © (2013) Trans Tech Publications, Switzerland.
关键词	Cell culture Mass spectrometry Nanotechnology 1H NMR and 13C NMR spectra Anti-tumor activities Anti-tumors Antitumor drugs Cyclodepsipeptides Hepatocellular carcinoma cell Lymphoma cells Natural products Paecilodepsipeptide A Retrosynthesis Total synthesis
DOI	10.4028/www.scientific.net/AMR.643.92
收录类别	EI
语种	英语
EI入藏号	20130615987719
EI主题词	Nuclear magnetic resonance spectroscopy
ISSN	10226680
来源库	Compendex
分类代码	761 Nanotechnology - 801 Chemistry - 801.2 Biochemistry - 932.2 Nuclear Physics
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	会议论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/117744
专题	生命科学与工程学院
作者单位	1.Lanzhou University of Technology, Lanzhou, China; 2.Lanzhou Jinchuan New Materials Co., Ltd., Lanzhou, China
第一作者单位	兰州理工大学
推荐引用方式 GB/T 7714	Yang, Mingjun,Wang, Yonggang,Liu, Xiaofeng,et al. Synthesis and anti-tumor activity of cyclodepsipeptides paecilodepsipeptide A[C]:Trans Tech Publications, P.O. Box 1254, Clausthal-Zellerfeld, D-38670, Germany,2013:92-96.