Antitumor activity of different fractions of Cynanchum komarocii in vitro

doi:10.2495/HHME130432

	Antitumor activity of different fractions of Cynanchum komarocii in vitro
	Pu, Xiuying; Wang, Hengrui; Yu, Shuang; Fan, Wenbo
	2014
会议名称	2013 International Conference on Human Health and Medical Engineering, HHME 2013
会议录名称	WIT Transactions on Biomedicine and Health
卷号	18
页码	731-735
会议日期	December 7, 2013 - December 8, 2013
会议地点	Wuhan, China
出版者	WITPress
摘要	The antitumor activity of Cynanchum komarovii has not been previously examined in vitro system. The aim of this study was to evaluate the antitumor potential of C. komarovii by studying in vitro antitumor activity of the different fractions extract. The proliferation inhibition rate and IC50 of HepG2 cells in vitro were investigated by the MTT assay of the different fractions of C. komarovii. Our study revealed that the petroleum ether, chloroform, ethyl acetate, acetone, and 70% ethanol extract of C. komarovii showed significant antitumor activity towards HepG2 cells, and the proliferation inhibition rates, respectively were 63.84%, 64.18%, 63.00%, 74.80%, and 59.60% in the 1000 μg/mL of extract and the IC50 values were 459.88, 388.87, 399.27, 196.66, and 289.17 μg/mL, respectively. It indicated that acetone parts had better inhibit growth effect on HepG2 cells. © 2014 WIT Press.
关键词	Biomedical engineering Anti-tumor activities Anti-tumors Cynanchum komarocii Ethanol extract In-vitro MTT Petroleum ether Proliferation inhibition
DOI	10.2495/HHME130432
收录类别	EI
语种	英语
EI入藏号	20143218035764
EI主题词	Acetone
ISSN	17433525
来源库	Compendex
分类代码	461.1 Biomedical Engineering - 804.1 Organic Compounds
引用统计	无
文献类型	会议论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/117371
专题	生命科学与工程学院
作者单位	Life Science and Engineering College, Lanzhou University of Technology, Lanzhou, China
第一作者单位	兰州理工大学
推荐引用方式 GB/T 7714	Pu, Xiuying,Wang, Hengrui,Yu, Shuang,et al. Antitumor activity of different fractions of Cynanchum komarocii in vitro[C]:WITPress,2014:731-735.