Heparin-like macromolecules for the modification of anticoagulant biomaterials

doi:10.1002/mabi.201100249

	Heparin-like macromolecules for the modification of anticoagulant biomaterials
	Ran, Fen1,2,3 ; Nie, Shengqiang 1,2; Li, Jie 3; Su, Baihai 1,2; Sun, Shudong 1,2; Zhao, Changsheng 1,2
	2012
发表期刊	Macromolecular Bioscience
ISSN	16165187
卷号	12 期号:1 页码:116-125
摘要	A heparin-like structured macromolecule (HLSM) is synthesized by RAFT polymerization using carboxyl-terminated trithiocarbonate as the RAFT agent. The HLSM can be directly blended with PES in DMAC to prepare flat-sheet membrane by means of a liquid-liquid phase separation technique. The synthesized polymeric material retard blood clotting and the modified membrane exhibits good anticoagulant ability due to the existence of the important functional groups -SO3H, -COOH and -OH. The anionic groups on the membrane surface may bind coagulation factors and thus improve anticoagulant ability. The results indicate that the HLSM has potential to improve the anticoagulant properties of biomaterials and to be applied in blood purification including hemodialysis and bioartificial liver supports. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
关键词	Artificial organs Biocompatibility Living polymerization Macromolecules Phase separation Polysaccharides Anticoagulant properties Bioartificial liver Blood compatibility Coagulation factor Flat sheet membranes Liquid-liquid phase separation Polyethersulfone membrane RAft polymerization
DOI	10.1002/mabi.201100249
收录类别	EI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[50973070] ; National Natural Science Foundation of China[51073105] ; National Natural Science Foundation of China[30900691]
WOS研究方向	Biochemistry & Molecular Biology ; Materials Science ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science
WOS记录号	WOS:000298843000014
出版者	Wiley-VCH Verlag
EI入藏号	20120214673299
EI主题词	Blood
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.9.1 Immunology ; 462.4 Prosthetics ; 641.1 Thermodynamics ; 815 Polymers and Polymer Science
来源库	Compendex
分类代码	461.2 Biological Materials and Tissue Engineering - 461.9.1 Immunology - 462.4 Prosthetics - 641.1 Thermodynamics - 815 Polymers and Polymer Science
引用统计	被引频次：83[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/111402
专题	省部共建有色金属先进加工与再利用国家重点实验室材料科学与工程学院
通讯作者	Sun, Shudong
作者单位	1.Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China; 2.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China; 3.Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Peoples R China
第一作者单位	省部共建有色金属先进加工与再利用国家重点实验室
推荐引用方式 GB/T 7714	Ran, Fen,Nie, Shengqiang,Li, Jie,et al. Heparin-like macromolecules for the modification of anticoagulant biomaterials[J]. Macromolecular Bioscience,2012,12(1):116-125.
APA	Ran, Fen,Nie, Shengqiang,Li, Jie,Su, Baihai,Sun, Shudong,&Zhao, Changsheng.(2012).Heparin-like macromolecules for the modification of anticoagulant biomaterials.Macromolecular Bioscience,12(1),116-125.
MLA	Ran, Fen,et al."Heparin-like macromolecules for the modification of anticoagulant biomaterials".Macromolecular Bioscience 12.1(2012):116-125.