Institutional Repository of Coll Life & Sci Engn
Bioavailability and pharmacokinetics of alantolactone from Inula helenium in rats following intravenous and oral administrations | |
Zhang Xinguo1; Liu Jinweng1; Kou Fei1; Wang Qianglin1; Liu Ziyu1; Li Jianyong2 | |
2017 | |
发表期刊 | Journal of Chinese Pharmaceutical Sciences |
ISSN | 1003-1057 |
卷号 | 26期号:4页码:284-290 |
摘要 | Alantolactone, as the principal constituent of Inula Helenium L, has been shown various pharmacologic activities, such as anti-inflammatory and deworming. In the present study, we developed a high performance liquid chromatography (HPLC) method for the determination of alantolactone in rat plasma, and pharmacokinetics of alantolactone was investigated after intravenous and oral administrations to Wistar rats. Separation was achieved on C_(18) column (4.6 mm*250 mm, 5.0 mum) using a mobile phase consisting of methanol-water (70:30, v/v) at a flow rate of 1.0 mL/min. The wavelength of the ultraviolet detector was set at 239 nm. The excellent linearity was found over a concentration range of 0.08-10 mug/mL (R~2 = 0.9998). The intra- and inter-day precisions were good, and the RSD was lower than 2.27%. The mean absolute recovery of alantolactone in plasma ranged from 88.09% to 95.57%. After intravenous administration, alantolactone showed rapid systemic clearance (CL (0.110.014) L/h/kg) and small volume of distribution (Vd (0.710.14) L/kg). The biological half life (t_(1/2)) was 56.24 min. After oral administration, alantolactone showed rapid oral absorption in rats, with a short T_(max) of (45.020.88) and (45.130.39) min for 14 and 28 mg/kg, respectively. The bioavailability of alantolactone in rats was 50.88%, indicating that alantolactone was orally available. |
关键词 | HPLC Alantolactone Pharmacokinetic Bioavailability HPLC |
收录类别 | CSCD |
语种 | 英语 |
WOS研究方向 | Pharmacology & Pharmacy |
WOS类目 | PHARMACOLOGY PHARMACY |
CSCD记录号 | CSCD:5971601 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://ir.lut.edu.cn/handle/2XXMBERH/72570 |
专题 | 生命科学与工程学院 |
作者单位 | 1.Lanzhou University of Technology, School of Life Science and Engineering, Key Laboratory of Herbal-Tebitan Drug Screening and Deep Processing of Gansu Province, Lanzhou, Gansu 730050, China 2.Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture;;Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, Gansu 730050, China |
第一作者单位 | 生命科学与工程学院 |
第一作者的第一单位 | 生命科学与工程学院 |
推荐引用方式 GB/T 7714 | Zhang Xinguo,Liu Jinweng,Kou Fei,et al. Bioavailability and pharmacokinetics of alantolactone from Inula helenium in rats following intravenous and oral administrations[J]. Journal of Chinese Pharmaceutical Sciences,2017,26(4):284-290. |
APA | Zhang Xinguo,Liu Jinweng,Kou Fei,Wang Qianglin,Liu Ziyu,&Li Jianyong.(2017).Bioavailability and pharmacokinetics of alantolactone from Inula helenium in rats following intravenous and oral administrations.Journal of Chinese Pharmaceutical Sciences,26(4),284-290. |
MLA | Zhang Xinguo,et al."Bioavailability and pharmacokinetics of alantolactone from Inula helenium in rats following intravenous and oral administrations".Journal of Chinese Pharmaceutical Sciences 26.4(2017):284-290. |
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