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Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice
Guo, Tao1,2; Deng, Yun-Xia1; Xie, Hui1; Yao, Chun-Yan1; Cai, Cheng-Cheng1; Pan, Sheng-li1; Wang, Yang-Lin3
2011-04
发表期刊FITOTERAPIA
ISSN0367-326X
卷号82期号:3页码:347-351
摘要Zanthoxylum armatum DC. is a traditional Chinese medicine that is prescribed to alleviate pain and treat inflammatory disorders. This species is distributed mainly in the southeast and southwest regions of China. In the present study, we found that ethyl acetate fraction of ethanolic extract of Z. armatum could significantly decrease acetic acid-induced writhing numbers, and suppress formalin induced licking times in the first phase at the highest dose and in the second phase at all tested doses. This observation revealed that Z. armatum extract possessed powerful antinociceptive activity. The mechanisms of the antinociceptive effect might be mainly involved in the periphery inflammatory analgesic. In addition, the ethyl acetate fraction also inhibited xylene-induced ear swelling in a dose-dependent manner in mice. Eight lignans [eudesmin, horsfieldin, fargesin, kobusin, sesamin, asarinin, planispine A. and pinoresinol-di-3,3-dimethylallyl] were identified as major components of the ethyl acetate fraction. Considering related studies reporting the anti-inflammatory activity for the identified lignans, lignan might be responsible for its anti-inflammatory activity. Our results confirm that the traditional use of Z. armatum in the treatment of inflammation and pain is warranted. (c) 2010 Elsevier B.V. All rights reserved.
关键词Zanthoxylum armatum Antinociception Anti-inflammatory HPLC Lignan
DOI10.1016/j.fitote.2010.11.004
收录类别SCI ; SCIE
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000288354700008
出版者ELSEVIER SCIENCE BV
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://ir.lut.edu.cn/handle/2XXMBERH/35119
专题兰州理工大学
通讯作者Pan, Sheng-li
作者单位1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China;
2.Lanzhou Univ Technol, Sch Life & Engn, Lanzhou 730050, Peoples R China;
3.Yumen Oilfield Hosp, Yumen 735019, Gansu, Peoples R China
第一作者单位生命科学与工程学院
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Guo, Tao,Deng, Yun-Xia,Xie, Hui,et al. Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice[J]. FITOTERAPIA,2011,82(3):347-351.
APA Guo, Tao.,Deng, Yun-Xia.,Xie, Hui.,Yao, Chun-Yan.,Cai, Cheng-Cheng.,...&Wang, Yang-Lin.(2011).Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice.FITOTERAPIA,82(3),347-351.
MLA Guo, Tao,et al."Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice".FITOTERAPIA 82.3(2011):347-351.
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