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| Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone) | |
Ran, Fen1,2,3 ; Nie, Shengqiang1,2; Zhao, Weifeng1,2; Li, Jie3; Su, Baihai1; Sun, Shudong1; Zhao, Changsheng1,2
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| 2011-09 | |
| Source Publication | ACTA BIOMATERIALIA
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| ISSN | 1742-7061 |
| Volume | 7Issue:9Pages:3370-3381 |
| Abstract | An amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone) (PVP-b-PMMA-b-PVP) was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The block co-polymer can be directly blended with polyethersulfone (PES) using dimethylacetamide (DMAC) as the solvent to prepare flat sheet and hollow fiber membranes using a liquid-liquid phase separation technique. The PVP block formed a brush on the surface of the blended membrane, while the PMMA block mingled with the PES macromolecules, which endowed the membrane with permanent hydrophilicity. After adding the as-prepared block co-polymer the modified membranes showed lower protein (bovine serum albumin) adsorption, suppressed platelet adhesion, and a prolonged blood coagulation time, and thereby the blood compatibility was improved. Furthermore, the modified PES membranes showed good cytocompatibility, ultrafiltration and protein anti-fouling properties. These results suggest that surface modification of PES membranes by blending with the amphiphilic triblock co-polymer PVP-b-PMMA-b-PVP allows practical application of these membranes with good biocompatibility in the field of blood purification, such as hemodialysis and bio-artificial liver support. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| Keyword | Polyethersulfone membrane Amphiphilic triblock co-polymer Ultrafiltration Blood compatibility Cytocompatibility |
| DOI | 10.1016/j.actbio.2011.05.026 |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| Funding Project | Sichuan Youth Science and Technology Foundation[08ZQ026-038] |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Materials Science, Biomaterials |
| WOS ID | WOS:000294040900014 |
| Publisher | ELSEVIER SCI LTD |
| Document Type | 期刊论文 |
| Identifier | https://ir.lut.edu.cn/handle/2XXMBERH/35058 |
| Collection | 材料科学与工程学院 省部共建有色金属先进加工与再利用国家重点实验室 |
| Corresponding Author | Zhao, Changsheng |
| Affiliation | 1.Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China 2.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610065, Peoples R China 3.Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Peoples R China |
| First Author Affilication | State Key Laboratory Of Gansu Advanced Non-Ferrous Metal Materials |
| Recommended Citation GB/T 7714 | Ran, Fen,Nie, Shengqiang,Zhao, Weifeng,et al. Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone)[J]. ACTA BIOMATERIALIA,2011,7(9):3370-3381. |
| APA | Ran, Fen.,Nie, Shengqiang.,Zhao, Weifeng.,Li, Jie.,Su, Baihai.,...&Zhao, Changsheng.(2011).Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone).ACTA BIOMATERIALIA,7(9),3370-3381. |
| MLA | Ran, Fen,et al."Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone)".ACTA BIOMATERIALIA 7.9(2011):3370-3381. |
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