Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review

doi:10.1016/j.envres.2018.11.040

	Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review
	Ben, Yujie 1,2,3; Fu, Caixia 1,3; Hu, Min 1,3,4; Liu, Lei 1,3,5; Wong, Ming Hung 1,3,6; Zheng, Chunmiao 1,3
	2019-02
发表期刊	ENVIRONMENTAL RESEARCH
ISSN	0013-9351
卷号	169 页码:483-493
摘要	The extensive use of antibiotics leading to the rapid spread of antibiotic resistance poses high health risks to humans, but to date there is still lack of a quantitative model to properly assess the risks. Concerns over the health risk of antibiotic residues in the environment are mainly (1) the potential hazard of ingested antibiotic residues in the environment altering the human microbiome and promoting emergence and selection for bacteria resistance inhabiting the human body, and (2) the potential hazard of creating a selection pressure on environmental microbiome and leading to reservoirs of antibiotic resistance in the environment. We provide a holistic view of health risk assessment of antibiotic resistance associated with antibiotic residues in the environment in contrast with that of the antibiotic resistant bacteria and discuss the main knowledge gaps and the future research that should be prioritized to achieve the quantitative risk assessment. We examined and summarized the available data and information on the four core elements of antibiotic resistance associated with antibiotic residues in the environment: hazard identification, exposure assessment, dose-response assessment, and risk characterization. The data required to characterize the risks of antibiotic residues in the environment is severely limited. The main future research needs have been identified to enable better assessments of antibiotic resistance associated with antibiotic residues in the environment: (1) establishment of a standardized monitoring guide of antibiotic residues and antibiotic resistance in the environment, (2) derivation of the relationship between antibiotic levels and pathogenic antibiotic-resistance development in different settings, and (3) establishment of the dose-response relationship between pathogenic antibiotic resistant bacteria and various infection diseases. After identification of key risk determinant parameters, we propose a conceptual framework of human health risk assessments of antibiotic residues in the environment.
关键词	Antibiotic residues Antibiotic resistance Exposure assessment Health risk assessment
DOI	10.1016/j.envres.2018.11.040
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[41330632]
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health
WOS记录号	WOS:000458592200051
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	被引频次：535[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/32148
专题	兰州理工大学
通讯作者	Zheng, Chunmiao
作者单位	1.Southern Univ Sci & Technol, Sch Environm Sci & Engn, Guangdong Prov Key Lab Soil & Groundwater Pollut, Shenzhen 518055, Peoples R China; 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100190, Peoples R China; 3.Southern Univ Sci & Technol, Sch Environm Sci & Engn, State Environm Protect Key Lab Integrated Surface, Shenzhen 518055, Peoples R China; 4.Lanzhou Univ Technol, Sch Civil Engn, Lanzhou 730050, Gansu, Peoples R China; 5.Univ Hong Kong, Environm Biotechnol Lab, Hong Kong, Peoples R China; 6.Educ Univ Hong Kong, Dept Sci & Environm Studies, CHEER, Tai Po, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Ben, Yujie,Fu, Caixia,Hu, Min,et al. Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review[J]. ENVIRONMENTAL RESEARCH,2019,169:483-493.
APA	Ben, Yujie,Fu, Caixia,Hu, Min,Liu, Lei,Wong, Ming Hung,&Zheng, Chunmiao.(2019).Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review.ENVIRONMENTAL RESEARCH,169,483-493.
MLA	Ben, Yujie,et al."Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review".ENVIRONMENTAL RESEARCH 169(2019):483-493.