A positive feedback circuit comprising p21 and HIF-1 alpha aggravates hypoxia-induced radioresistance of glioblastoma by promoting Glut1/LDHA-mediated glycolysis

doi:10.1096/fj.202101736R

IR > 研究生院

	A positive feedback circuit comprising p21 and HIF-1 alpha aggravates hypoxia-induced radioresistance of glioblastoma by promoting Glut1/LDHA-mediated glycolysis
	Jin, Xiaodong 1,2,3,4,5; Kuang, Yanbei 1,2,3,4; Li, Linying 1,2,3,4; Li, Hongbin6 ; Zhao, Ting 1,2,3,4; He, Yufang 7; Di, Cuixia 1,2,3,4,5; Kang, Jian8 ; Yuan, Lingyan 1; Yu, Boyi 1,2,3,4
	2022-03
发表期刊	FASEB JOURNAL
ISSN	0892-6638
卷号	36 期号:3
摘要	The radioresistance induced by hypoxia is the major obstacle in the successful treatment of cancer radiotherapy. p21 was initially identified as a widespread inhibitor of cyclin-dependent kinases, through which mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. In this study, we discovered a novel function of p21, which participated in the regulation of metabolic pathways under hypoxia. We found that p21 was upregulated in glioblastoma (GBM) cells under hypoxic conditions, which enhanced the radioresistance of GBM cells. In principle, HIF-1 alpha is bound directly to the hypoxia response elements (HREs) of the p21 promoter to enhance its transcription activity, in turn, p21 also promoted the transcription of HIF-1 alpha at the mRNA level and maintained HIF-1 alpha function under oxygen deficiency. The positive correlation between p21 and HIF-1 alpha augmented Glut1/LDHA-mediated glycolysis and aggravated the radioresistance of GBM cells. Thus, our results constructed a positive feedback circuit comprising p21/HIF-1 alpha that might play a key role in enhancing the radioresistance of GBM under hypoxia.
关键词	glioblastoma glycolysis HIF-1 alpha hypoxia p21 radioresistance
DOI	10.1096/fj.202101736R
收录类别	SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS记录号	WOS:000761250800015
出版者	WILEY
来源库	WOS
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/158125
专题	研究生院能源与动力工程学院生命科学与工程学院
通讯作者	Li, Qiang
作者单位	1.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China; 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China; 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou, Gansu, Peoples R China; 4.Univ Chinese Acad Sci, Beijing, Peoples R China; 5.Lanhai Nucl Med Res Ctr, Putian, Peoples R China; 6.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Peoples R China; 7.Third Hosp Gansu Prov, Lanzhou, Peoples R China; 8.Lanzhou Univ Technol, Coll Energy & Power Engn, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Jin, Xiaodong,Kuang, Yanbei,Li, Linying,et al. A positive feedback circuit comprising p21 and HIF-1 alpha aggravates hypoxia-induced radioresistance of glioblastoma by promoting Glut1/LDHA-mediated glycolysis[J]. FASEB JOURNAL,2022,36(3).
APA	Jin, Xiaodong.,Kuang, Yanbei.,Li, Linying.,Li, Hongbin.,Zhao, Ting.,...&Li, Qiang.(2022).A positive feedback circuit comprising p21 and HIF-1 alpha aggravates hypoxia-induced radioresistance of glioblastoma by promoting Glut1/LDHA-mediated glycolysis.FASEB JOURNAL,36(3).
MLA	Jin, Xiaodong,et al."A positive feedback circuit comprising p21 and HIF-1 alpha aggravates hypoxia-induced radioresistance of glioblastoma by promoting Glut1/LDHA-mediated glycolysis".FASEB JOURNAL 36.3(2022).