Photocatalytic degradation kinetics and mechanism of antivirus drug-lamivudine in TiO2 dispersion
An, Taicheng1; An, Jibin1,2,4; Yang, Hai1,4; Li, Guiying1; Feng, Huixia2; Nie, Xiangping3
Source PublicationJournal of Hazardous Materials
AbstractPhotocatalytic degradation kinetics of antivirus drug-lamivudine in aqueous TiO2 dispersions was systematically optimized by both single-variable-at-a-time and central composite design based on the response surface methodology. Three variables, TiO2 content, initial pH and lamivudine concentration, were selected to determine the dependence of degradation efficiencies of lamivudine on independent variables. Response surface methodology modeling results indicated that degradation efficiencies of lamivudine were highly affected by TiO2 content and initial lamivudine concentration. The highest degradation efficiency was achieved at suitable amount of TiO2 and with maintaining initial lamivudine concentration to a minimum. In addition, the contribution experiments of various primary reactive species produced during the photocatalysis were investigated with the addition of different scavengers and found that hydroxyl radicals was the major reactive species involved in lamivudine degradation in aqueous TiO2. Six degradation intermediates were identified using HPLC/MS/MS, and photocatalytic degradation mechanism of lamivudine was proposed by utilizing collective information from both experimental results of HPLC/MS/MS, ion chromatography as well as total organic carbon and theoretical data of frontier electron densities and point charges. © 2011 Elsevier B.V.
KeywordComputer viruses Dispersions Efficiency Enzyme kinetics Ion chromatography Kinetics Mechanisms Organic carbon Oxide minerals Surface properties Titanium dioxide Central composite designs Degradation efficiency Degradation intermediates Frontier electron densities Lamivudine Photo catalytic degradation Photocatalytic degradation mechanism Response surface methodology
Indexed ByEI ; SCIE
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000298200400029
PublisherElsevier B.V., Netherlands
EI Accession Number20114814568627
EI KeywordsDegradation
EI Classification Number482.2 Minerals ; 601.3 Mechanisms ; 801 Chemistry ; 802.2 Chemical Reactions ; 804.1 Organic Compounds ; 804.2 Inorganic Compounds ; 913.1 Production Engineering ; 931 Classical Physics ; Quantum Theory ; Relativity ; 951 Materials Science
Document Type期刊论文
Affiliation1.State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environmental Resources Utilization and Protection, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China;
2.College of Petrochemical Technology, Lanzhou University of Technology, Lanzhou 730050, China;
3.Institute of Hydrobiology, Jinan University, Guangzhou 510632, China;
4.Graduate School of Chinese Academy of Sciences, Beijing 100049, China
Recommended Citation
GB/T 7714
An, Taicheng,An, Jibin,Yang, Hai,et al. Photocatalytic degradation kinetics and mechanism of antivirus drug-lamivudine in TiO2 dispersion[J]. Journal of Hazardous Materials,2011,197:229-236.
APA An, Taicheng,An, Jibin,Yang, Hai,Li, Guiying,Feng, Huixia,&Nie, Xiangping.(2011).Photocatalytic degradation kinetics and mechanism of antivirus drug-lamivudine in TiO2 dispersion.Journal of Hazardous Materials,197,229-236.
MLA An, Taicheng,et al."Photocatalytic degradation kinetics and mechanism of antivirus drug-lamivudine in TiO2 dispersion".Journal of Hazardous Materials 197(2011):229-236.
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