Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis

doi:10.3389/fonc.2021.772915

IR > 外国语学院

	Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis
	Li, Ruyi 1; Song, Xin2 ; Guo, Yanan 3,4; Song, Peng 3,4; Duan, Dongzhu 5,6; Chen, Zhe-Sheng 7
	2021-10-22
发表期刊	FRONTIERS IN ONCOLOGY
ISSN	2234-943X
卷号	11
摘要	Tumor-associated angiogenesis is a key target for anti-cancer therapy. The imbalance between pro-angiogenic and anti-angiogenic signals elicited by tumor cells or tumor microenvironment always results in activating angiogenic switch. Tumor angiogenesis functions in multi-aspects of tumor biology, including endothelial cell apoptosis, tumor metastasis, and cancer stem cell proliferation. Numerous studies have indicated the important roles of inexpensive and less toxic natural products in targeting tumor angiogenesis-associated cytokines and apoptotic signaling pathways. Our current knowledge of tumor angiogenesis is based mainly on experiments performed on cells and animals, so we summarized the well-established models for angiogenesis both in vitro and in vivo. In this review, we classified and summarized the anti-angiogenic natural agents (Polyphenols, Polysaccharides, Alkaloids, Terpenoids, Saponins) in targeting various tumor types according to their chemical structures at present, and discussed the mechanistic principles of these natural products on regulating angiogenesis-associated cytokines and apoptotic signaling pathways. This review is to help understanding the recent progress of natural product research for drug development on anti-tumor angiogenesis.
关键词	tumor angiogenesis natural products angiogenic factors endothelial cell apoptosis anti-angiogenic mechanism chemical structures
DOI	10.3389/fonc.2021.772915
收录类别	SCIE
语种	英语
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000716482600001
出版者	FRONTIERS MEDIA SA
来源库	WOS
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/149989
专题	外国语学院
通讯作者	Song, Peng; Duan, Dongzhu; Chen, Zhe-Sheng
作者单位	1.Zhengzhou Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Zhengzhou, Peoples R China; 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Peoples R China; 3.Gansu Univ Chinese Med, Res Ctr Tradit Chinese Med Gansu Prov, Lanzhou, Peoples R China; 4.Gansu Univ Chinese Med, Affiliated Hosp, Key Lab Prevent & Treatment Chron Dis Tradit Chin, Lanzhou, Peoples R China; 5.Baoji Univ Arts & Sci, Shaanxi Key Lab Phytochem, Baoji, Peoples R China; 6.Baoji Univ Arts & Sci, Coll Chem & Chem Engn, Baoji, Peoples R China; 7.St Johns Univ, Coll Pharm & Hlth Sci, Queens, NY 11439 USA
推荐引用方式 GB/T 7714	Li, Ruyi,Song, Xin,Guo, Yanan,et al. Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis[J]. FRONTIERS IN ONCOLOGY,2021,11.
APA	Li, Ruyi,Song, Xin,Guo, Yanan,Song, Peng,Duan, Dongzhu,&Chen, Zhe-Sheng.(2021).Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis.FRONTIERS IN ONCOLOGY,11.
MLA	Li, Ruyi,et al."Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis".FRONTIERS IN ONCOLOGY 11(2021).