电化学场刺激表面引发原子转移自由基聚合构筑血液相容性聚醚砜膜仿生表面
Project Number51463012
冉奋
Abstract治疗与血液相关的疾病需要利用血液净化装置(如血液透析、血液滤过和血浆分离等),其技术核心是膜关键材料。临床上普遍使用的聚醚砜膜材料具有优异的物理机械性能、物化稳定性和成膜性能,但其血液相容性尤其是抗凝血性能仍然不够理想、不够持久,而基于共混两亲性嵌段共聚物的改性方法难以实现表面功能结构的可控制备。本项目提出采用电化学场刺激表面引发原子转移自由基聚合(SI-eATRP)在膜表面引入功能性分子刷,模拟血管内壁结构以构筑具有一定亲疏水平衡、电荷密度和多糖结构的抗凝血仿生表面。SI-eATRP聚合技术在保持共混工艺优点的前提下,将电化学和可控聚合成功联姻,实现功能性聚合物膜表面的可控构筑与制备,预计将解决膜材料表面结构、性质与血液相容性关系的基础科学问题。和传统的表面化学接枝相比,本项目所采用的方法简单有效、可改性中空纤维膜,有望制备易于批量生产的血液相容性聚醚砜膜材料,并应用于血液净化领域。【英文摘要】Bloodpurificationapparatus,suchashemodialysis,hemofiltationandbloodseperation,isoftenneededtotreattheblood-assotiateddisease,whiletheprousmembraneisitskeycomponent.Amongthematerialsused,polyethersulfone(PES)showoutstandingoxidative,thermalandhydrolyticstabilityaswellasgoodmechanicalandfilm-formingproperties,andiswidelyusedinbloodpurificationfields.However,thehemocompatibilityofPESisinadequateandunstable,andinjectionsofanticoagulantsareneededduringhemodialysis.Hence,preparationofbionicsurfaceforhemocompatibilityPESmembranesviasurface-initiatedandelectrochemicallymediatedatom-transferradicalpolymerization(SI-eATRP)isproposedinthisproject.Itaimedatconstructingamembranesurfacewithcertainhydrophilicity,chargedensityandpolysacchardestructuretosimulatesurfaceperformanceofbloodvesselwall.Comparedwiththemethodofdirectblendingamphiphilicblockcopolymerasadditives,theproposedSI-eATRPmethodcombininglivingpolymerizationandelectrochemistrywillarchitecture-controlledfabricatethemembranesurface,andsystematicallyinvestigatetheeffectsofsurfacestructureandpropertiesonhemocompatibility.Furthermore,comparedwiththeconventionalchemicalgraftmodifyingmethod,theproposedmethodissimpleandefficient,andcanbeusedtomodifythehollowfibermembranes.Basedonabovestudies,thehemocompatibilityPESmembranemaybeprepared,whichcanbeeasilyproducedwithlargequantities,andusedinbloodpurificationfields.
Subtype地区科学基金项目
Project Source国家自然科学基金
2015-01
End Date2018-12
MOST Discipline Catalogue10 - 材料科学 ; 1003 - 有机高分子材料
Host Institution兰州理工大学
Project Funding490000.0
CountryCN
Language中文
Document Type项目
Identifierhttp://ir.lut.edu.cn/handle/2XXMBERH/64713
Collection材料科学与工程学院
Recommended Citation
GB/T 7714
冉奋.电化学场刺激表面引发原子转移自由基聚合构筑血液相容性聚醚砜膜仿生表面.2015.
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