A Mixed Micellar Liquid Chromatography with Direct Injection for Rapid Analysis of Eight Sulfonamides in Milk
Duan, Xiaoyun1,2; Liu, Xiaofeng2; Dong, Yue1; Duan, Tianjiao2; Zhang, Jing1; He, Shujuan1; Yang, Fatang1; Dong, Yuming1
2020-03-02
Source PublicationFOOD ANALYTICAL METHODS
ISSN1936-9751
Volume13Issue:5Pages:1148-1158
AbstractIn this work, an isocratic mixed micellar liquid chromatography method was first applied to the separation of eight sulfonamides in milk. Mixed anionic and nonionic surfactants were used as mobile phase additives. Because proteins in the milk can be dissolved by the micelles, the milk samples can be directly injected into the chromatographic system after being simply diluted 10 times with 0.1 M sodium dodecyl sulfate solution. Besides, three-phase equilibrium theory was firstly used to explain the retention mechanism of sulfonamides in the mixed micellar liquid chromatography. The optimized mobile phase was an aqueous solution (0.04 M sodium dodecyl sulfate and 0.01 M polyoxyethylene lauryl ether) containing 20 mM NaH2PO4 with 10% (v/v) of n-propanol at pH 3.0. The separation was performed on a Venusil XBP C18 column (250 x 4.6 mm, i.d., 5 mu m). The proposed mixed micellar liquid chromatography method was validated in terms of linear ranges (20-2500 mu g/L), limit of detections (1.9-8.0 mu g/L), limit of quantitations (6.1-27 mu g/L), recoveries (84-105%), intra- and inter-precisions (RSD < 6.0%, RSD < 9.3%). The established method, which is rapid, low-cost, and environmentally friendly, provides an alternative way for rapid separation of sulfonamides within 15 min, and it does not require the complex gradient elution.
KeywordSulfonamides Micellar liquid chromatography Milk Sample preparation Retention mechanism
DOI10.1007/s12161-020-01733-3
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000517683100002
PublisherSPRINGER
Document Type期刊论文
Identifierhttp://ir.lut.edu.cn/handle/2XXMBERH/60008
Collection生命科学与工程学院
Corresponding AuthorDong, Yuming
Affiliation1.Lanzhou Univ, Sch Pharm, Lanzhou, Peoples R China
2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Peoples R China
First Author AffilicationColl Life & Sci Engn
Recommended Citation
GB/T 7714
Duan, Xiaoyun,Liu, Xiaofeng,Dong, Yue,et al. A Mixed Micellar Liquid Chromatography with Direct Injection for Rapid Analysis of Eight Sulfonamides in Milk[J]. FOOD ANALYTICAL METHODS,2020,13(5):1148-1158.
APA Duan, Xiaoyun.,Liu, Xiaofeng.,Dong, Yue.,Duan, Tianjiao.,Zhang, Jing.,...&Dong, Yuming.(2020).A Mixed Micellar Liquid Chromatography with Direct Injection for Rapid Analysis of Eight Sulfonamides in Milk.FOOD ANALYTICAL METHODS,13(5),1148-1158.
MLA Duan, Xiaoyun,et al."A Mixed Micellar Liquid Chromatography with Direct Injection for Rapid Analysis of Eight Sulfonamides in Milk".FOOD ANALYTICAL METHODS 13.5(2020):1148-1158.
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