Bioassay-guided Isolation and Identification of a Acetylcholinesterase Inhibitors from Calophyllum polyanthum

doi:10.4028/www.scientific.net/AMR.634-638.1225

	Bioassay-guided Isolation and Identification of a Acetylcholinesterase Inhibitors from Calophyllum polyanthum
	Zhang, Fei; Ren, Hai-Wei; Wang, Yong-Gang; Wang, Rong; Sheng, Jie
	2013
会议名称	ADVANCES IN CHEMICAL, MATERIAL AND METALLURGICAL ENGINEERING, PTS 1-5
会议录名称	ADVANCES IN CHEMICAL, MATERIAL AND METALLURGICAL ENGINEERING, PTS 1-5
卷号	634-638
页码	1225-1228
出版地	LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND
出版者	TRANS TECH PUBLICATIONS LTD
摘要	A significant acetylcholinesterase inhibitory activity was observed for the Ethanolic extract from the leaves of Calophyllum polyanthum by using TLC bioautographic method. Further bioassay-guided isolation of this extract using TLC bioautographic method resulted in obtaining a pyranochromanone, apetalic acid (1). The structure of 1 was identified by comparison of it's spectral characteristics with previous reports. The concentration required for 50% inhibition of 1 was 0.95 mM, determined by a microplate assay. The anti-acetylcholinesterase aity of compound 1 was weak, but it was the first pyranochromanone which have anti-acetyl cholinesterase activity. As a new leading compound, it can be modified and transformed to obtain more potently active compounds.
关键词	Calophyllum polyanthum Acetylcholinesterase inhibitor Apetalic acid TLC bioautographic method Pyranochromanone
DOI	10.4028/www.scientific.net/AMR.634-638.1225
语种	英语
WOS研究方向	Engineering ; Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Engineering, Chemical ; Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000322420400239
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	会议论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/36936
专题	生命科学与工程学院科学技术处（军民融合领导小组办公室）学科建设与学位办公室党委组织部（党校、帮扶办）
通讯作者	Zhang, Fei
作者单位	Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China
第一作者单位	生命科学与工程学院
通讯作者单位	生命科学与工程学院
推荐引用方式 GB/T 7714	Zhang, Fei,Ren, Hai-Wei,Wang, Yong-Gang,et al. Bioassay-guided Isolation and Identification of a Acetylcholinesterase Inhibitors from Calophyllum polyanthum[C]. LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND:TRANS TECH PUBLICATIONS LTD,2013:1225-1228.