Impairments of cingulated cortex in the generalized tonic-clonic seizure epilepsy by combining morphological and functional connectivity magnetic resonance imaging

doi:10.3233/JIN-170026

IR > 计算机与通信学院

	Impairments of cingulated cortex in the generalized tonic-clonic seizure epilepsy by combining morphological and functional connectivity magnetic resonance imaging
	Ke, Ming1 ; Jin, Bixia 1; Liu, Guangyao 2; Yang, Xiaoping 3
	2017
发表期刊	JOURNAL OF INTEGRATIVE NEUROSCIENCE
ISSN	0219-6352
卷号	16 期号:4 页码:429-439
摘要	Previous studies suggested that the patients with generalized tonic-clonic seizure had structural abnormalities in the thalamus, cingulated cortex and some other specific brain regions. Concurrently, the abnormality in thalamocortical network and basal ganglia network has been found in idiopathic generalized epilepsy. The cingulated cortex, a nexus of information processing and regulation in human brain, is implicated in the propagation of generalized spike in IGE and the previous studies have suggested that the structural features and functional connectivity of the cingulated cortex have been changed. The aim of this study was to demonstrate the alterations in the cingulated cortex in generalized tonic-clonic seizure by combining morphological and functional connectivity magnetic resonance imaging. 19 patients with generalized tonic-clonic seizure and 19 age-and gender-matched healthy controls were involved in the study. The three-dimensional high-resolution T1-weighted magnetic resonance imaging data were acquired for voxel-based morphometry analysis, two-sample t-test run on the T1-weighted structural images revealed clusters exhibiting significant decreases in grey-matter volume in the generalized tonic-clonic seizure group, located within the cingulated cortex, thalamus, frontal lobe, temporal lobe, and cerebellum. The decreased gray matter volume in the cingulated cortex indicating that the cingulated cortex has structural impairments in generalized tonic-clonic seizure patients. The bilateral cingulated cortex, as detected with decreased gray matter volume in patients with generalized tonic-clonic seizure through voxel-based morphometry analysis, was selected as seed regions for functional connectivity analysis. Compared with controls, we found decreased functional connectivity to left anterior cingulated cortex (ROI1) in the cuneus, frontal lobe and precentral gyrus. There was no significant result when seeding at the right anterior cingulum gyrus (ROI2). The results of the ROI3 (left middle cingulum) revealed the significantly decreased functional connectivity in the parietal lobe and frontal lobe. Seeding at the ROI4 (right middle cingulum), decreased functional connectivity showed in the occipital lobe, temporal lobe, frontal lobe. Seeding at the ROI5 (left posterior cingulum), decreased functional connectivity showed in the temporal lobe and frontal lobe. Seeding at the ROI6 (right posterior cingulum), decreased functional connectivity showed in the cuneus and frontal lobe. We did not find any increased functional connectivity of the posterior cingulated cortex (ROI3-ROI6) for the generalized tonic-clonic seizure patients in comparison to the controls (p < 0.001). Our findings demonstrated that the abnormalities of the functional connectivity were likely to be related to the decreased gray matter volume in the cingulated cortex.
关键词	Epilepsy voxel-based morphometry cingulated cortex functional connectivity
DOI	10.3233/JIN-170026
收录类别	SCI ; SCIE
语种	英语
资助项目	National Science Foundation of China[61263047]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000407342900004
出版者	IOS PRESS
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/33467
专题	计算机与通信学院
通讯作者	Ke, Ming
作者单位	1.Lanzhou Univ Technol, Coll Comp & Commun, Lanzhou 730050, Gansu, Peoples R China; 2.Lanzhou Univ, Hosp 2, Dept Nucl Magnet Resonance, Lanzhou 733000, Gansu, Peoples R China; 3.Lanzhou Mil Command, Lanzhou Gen Hosp, Dept Imaging Diag, Lanzhou 730050, Gansu, Peoples R China
第一作者单位	计算机与通信学院
通讯作者单位	计算机与通信学院
第一作者的第一单位	计算机与通信学院
推荐引用方式 GB/T 7714	Ke, Ming,Jin, Bixia,Liu, Guangyao,et al. Impairments of cingulated cortex in the generalized tonic-clonic seizure epilepsy by combining morphological and functional connectivity magnetic resonance imaging[J]. JOURNAL OF INTEGRATIVE NEUROSCIENCE,2017,16(4):429-439.
APA	Ke, Ming,Jin, Bixia,Liu, Guangyao,&Yang, Xiaoping.(2017).Impairments of cingulated cortex in the generalized tonic-clonic seizure epilepsy by combining morphological and functional connectivity magnetic resonance imaging.JOURNAL OF INTEGRATIVE NEUROSCIENCE,16(4),429-439.
MLA	Ke, Ming,et al."Impairments of cingulated cortex in the generalized tonic-clonic seizure epilepsy by combining morphological and functional connectivity magnetic resonance imaging".JOURNAL OF INTEGRATIVE NEUROSCIENCE 16.4(2017):429-439.

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