Low dietary protein and high carbohydrate infant formula affects the microbial ecology of the large intestine in neonatal rats

doi:10.1139/cjm-2017-0242

	Low dietary protein and high carbohydrate infant formula affects the microbial ecology of the large intestine in neonatal rats
	Fan, Wenguang1 ; Ren, Haiwei1 ; Cao, Yingying1 ; Wang, Yonggang1 ; Huo, Guicheng 2
	2017-12
发表期刊	CANADIAN JOURNAL OF MICROBIOLOGY
ISSN	0008-4166
卷号	63 期号:12 页码:951-960
摘要	The aim of this study was to investigate the effects of a low dietary protein and high carbohydrate infant formula on the large intestine of neonatal rats. A total of 24 neonatal Sprague-Dawley rats (14-days-old) were randomly assigned to the low protein, high carbohydrate infant formula-fed group (I group) and a human breast milk-fed group (H group). After 7 days, we selected 6 rats at random from each group to study. No significantly different microbial colonization patterns were observed in the 2 groups at the phylum level. At the family level, Enterobacteriaceae and Bacteroidaceae were the dominant bacteria in I and H rats. While Bacteroides was the most abundant bacteria at the genus level, no significant difference was observed between the 2 groups. Methanoic acid, acetate, and butyrate increased in concentration in the I group compared with the H group. Protease activities, ammonia, and indole in the large intestine were lower in I rats than H rats. A significant increase in the expression of GADPH and decrease in the expression of aquaporin 8, aminopeptidase A, cathepsin F precursor, and ubiquitin carboxyl-terminal hydrolase FAF-Y were observed in I rats compared with H rats. These results suggest that a low protein diet could modulate the microbial ecology in the large intestine of neonatal rats.
关键词	Sprague-Dawley rats low protein and high carbohydrate infant formula microbiota metabolites gene expression
DOI	10.1139/cjm-2017-0242
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of Gansu Province[1610RJYA030]
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Immunology ; Microbiology
WOS类目	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Immunology ; Microbiology
WOS记录号	WOS:000415361600003
出版者	CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/32996
专题	生命科学与工程学院
通讯作者	Fan, Wenguang
作者单位	1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China 2.Northeast Agr Univ, Coll Food Sci, Harbin 150030, Heilongjiang, Peoples R China
第一作者单位	生命科学与工程学院
通讯作者单位	生命科学与工程学院
第一作者的第一单位	生命科学与工程学院
推荐引用方式 GB/T 7714	Fan, Wenguang,Ren, Haiwei,Cao, Yingying,et al. Low dietary protein and high carbohydrate infant formula affects the microbial ecology of the large intestine in neonatal rats[J]. CANADIAN JOURNAL OF MICROBIOLOGY,2017,63(12):951-960.
APA	Fan, Wenguang,Ren, Haiwei,Cao, Yingying,Wang, Yonggang,&Huo, Guicheng.(2017).Low dietary protein and high carbohydrate infant formula affects the microbial ecology of the large intestine in neonatal rats.CANADIAN JOURNAL OF MICROBIOLOGY,63(12),951-960.
MLA	Fan, Wenguang,et al."Low dietary protein and high carbohydrate infant formula affects the microbial ecology of the large intestine in neonatal rats".CANADIAN JOURNAL OF MICROBIOLOGY 63.12(2017):951-960.

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