Surfactin isoforms isolated from a mushroom derived Bacillus halotolerans DMG-7-2

doi:10.1080/14786419.2021.1926457

	Surfactin isoforms isolated from a mushroom derived Bacillus halotolerans DMG-7-2
	Zhou, Guo-Feng 1,2; Yang, Lin1 ; Zhang, Shu-Hua 2; Wang, Yi 3; Yang, Yu 2; Xu, Rui 2; Zhao, Xue 2; Nie, Dan 2; Shan, Junjie 2; Cui, Cheng-Bin 2
	2022-10-13
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
卷号	36 期号:20 页码:5222-5227
摘要	A new iso-C-14 [Val(2), Val(7)] surfactin isoform (1) together with eight known ones (2-9), was isolated from the culture of a mushroom derived bacterium, Bacillus halotolerans DMG-7-2. The structures of them were mainly elucidated by NMR and MS data, and the NMR data of 5 also was reported for the first time. The absolute configuration of 1 was determined by Marfey's analysis (for amino acid residues) and the C-13 NMR calculation of the two plausible epimers of 1 (for fatty acid). Compounds 1-9 showed moderate cytotoxicity against two human cancer cell lines (A549, MCF-7) and mice microglial BV2 cells, the IC50 values ranged from 8.91 to 33.00 mu M, and the IC50 values of the positive control 5-FU were 99.94, 71.49 and 0.12 mu M, respectively.
关键词	Surfactin isoform mushroom Cortinarius lucorum Bacillus halotolerans cytotoxicity
DOI	10.1080/14786419.2021.1926457
收录类别	SCIE ; SCOPUS
语种	英语
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Applied ; Chemistry, Medicinal
WOS记录号	WOS:000649632600001
出版者	TAYLOR & FRANCIS LTD
来源库	WOS
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.lut.edu.cn/handle/2XXMBERH/148220
专题	生命科学与工程学院
通讯作者	Yang, Lin; Li, Chang-Wei
作者单位	1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Peoples R China; 2.Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing, Peoples R China; 3.Ocean Univ China, Minist Educ, Key Lab Marine Drugs, Sch Med & Pharm, Qingdao, Peoples R China
第一作者单位	生命科学与工程学院
通讯作者单位	生命科学与工程学院
第一作者的第一单位	生命科学与工程学院
推荐引用方式 GB/T 7714	Zhou, Guo-Feng,Yang, Lin,Zhang, Shu-Hua,et al. Surfactin isoforms isolated from a mushroom derived Bacillus halotolerans DMG-7-2[J]. NATURAL PRODUCT RESEARCH,2022,36(20):5222-5227.
APA	Zhou, Guo-Feng.,Yang, Lin.,Zhang, Shu-Hua.,Wang, Yi.,Yang, Yu.,...&Li, Chang-Wei.(2022).Surfactin isoforms isolated from a mushroom derived Bacillus halotolerans DMG-7-2.NATURAL PRODUCT RESEARCH,36(20),5222-5227.
MLA	Zhou, Guo-Feng,et al."Surfactin isoforms isolated from a mushroom derived Bacillus halotolerans DMG-7-2".NATURAL PRODUCT RESEARCH 36.20(2022):5222-5227.