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| Multiple functions of p21 in cancer radiotherapy | |
Kuang, Yanbei1,2,3,4; Kang, Jian5 ; Li, Hongbin6; Liu, Bingtao1,2,3,4; Zhao, Xueshan7; Li, Linying1,2,3,4; Jin, Xiaodong1,2,3,4; Li, Qiang1,2,3,4
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| 2021-04 | |
| 发表期刊 | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
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| ISSN | 0171-5216 |
| 卷号 | 147期号:4页码:- |
| 摘要 | Background Greater than half of cancer patients experience radiation therapy, for both radical and palliative objectives. It is well known that researches on radiation response mechanisms are conducive to improve the efficacy of cancer radiotherapy. p21 was initially identified as a widespread inhibitor of cyclin-dependent kinases, transcriptionally modulated by p53 and a marker of cellular senescence. It was once considered that p21 acts as a tumour suppressor mainly to restrain cell cycle progression, thereby resulting in growth suppression. With the deepening researches on p21, p21 has been found to regulate radiation responses via participating in multiple cellular processes, including cell cycle arrest, apoptosis, DNA repair, senescence and autophagy. Hence, a comprehensive summary of the p21's functions in radiation response will provide a new perspective for radiotherapy against cancer. Methods We summarize the recent pertinent literature from various electronic databases, including PubMed and analyzed several datasets from Gene Expression Omnibus database. This review discusses how p21 influences the effect of cancer radiotherapy via involving in multiple signaling pathways and expounds the feasibility, barrier and risks of using p21 as a biomarker as well as a therapeutic target of radiotherapy. Conclusion p21's complicated and important functions in cancer radiotherapy make it a promising therapeutic target. Besides, more thorough insights of p21 are needed to make it a safe therapeutic target. |
| 关键词 | p21 Cell cycle Apoptosis DNA damage repair Cancer radiotherapy |
| DOI | 10.1007/s00432-021-03529-2 |
| 收录类别 | SCOPUS ; SCIE |
| 语种 | 英语 |
| WOS研究方向 | Oncology |
| WOS类目 | Oncology |
| WOS记录号 | WOS:000615118600001 |
| 出版者 | SPRINGER |
| 来源库 | WOS |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://ir.lut.edu.cn/handle/2XXMBERH/147294 |
| 专题 | 研究生院 能源与动力工程学院 生命科学与工程学院 |
| 通讯作者 | Jin, Xiaodong; Li, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China; 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China; 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.Lanzhou Univ Technol, Coll Energy & Power Engn, Lanzhou 730050, Peoples R China; 6.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China; 7.Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kuang, Yanbei,Kang, Jian,Li, Hongbin,et al. Multiple functions of p21 in cancer radiotherapy[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2021,147(4):-. |
| APA | Kuang, Yanbei.,Kang, Jian.,Li, Hongbin.,Liu, Bingtao.,Zhao, Xueshan.,...&Li, Qiang.(2021).Multiple functions of p21 in cancer radiotherapy.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,147(4),-. |
| MLA | Kuang, Yanbei,et al."Multiple functions of p21 in cancer radiotherapy".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 147.4(2021):-. |
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